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强化化疗和放疗常引起严重的口炎而影响治疗。作者对洗必泰含漱液预防该种口炎的效果进行了前瞻性的双盲随机分组对比研究。40名接受大剂量化疗及30名接受大剂量放疗的头颈癌患者,各分成2组,分别给予0.12%洗必泰含漱液及不含洗必泰的对照液。每日3次,每次15ml,含漱30s,连续3周。结果在化疗患者中,用洗必泰含漱液组至7天时,口腔粘膜炎发生率为16%;对照液组为42%。至14天时,洗必泰组为11%;对照液组为50%。至21天时,洗必泰组为7%;对照液组为50%。停用含漱液后1周
Intensive chemotherapy and radiotherapy often cause severe stomatitis and affect the treatment. The authors conducted a prospective, double-blind, randomized, and cohort study of the efficacy of chlorhexidine gargle in preventing this stomatitis. Forty patients with high-dose chemotherapy and 30 patients with head and neck cancer undergoing high-dose radiotherapy were divided into two groups and given 0.12% chlorhexidine gargle and control solution without chlorhexidine. 3 times a day, each 15ml, gargle 30s, for 3 weeks. Results In patients with chemotherapy, the incidence of oral mucositis was 16% with the chlorhexidine gargle group up to 7 days and 42% with the control group. By 14 days, the chlorhexidine group was 11%; the control group was 50%. By 21 days, the chlorhexidine group was 7%; the control group was 50%. 1 week after gargle release