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目的 :在内毒素休克发病过程中 ,肺动脉张力调控机制发生明显紊乱 ,表现为肺动脉压早期增高而晚期降低 ,对休克的预后有明显影响。我们的实验证实 ,内毒素血症早期 ( 6ｈ)大鼠肺动脉肌层有过氧亚硝基阴离子 (ＯＮＯＯ- )生成。ＯＮＯＯ- 为一氧化氮和超氧阴离子的快速非酶促反
OBJECTIVE: In the pathogenesis of endotoxic shock, obvious disturbance of pulmonary tone regulation mechanism occurs, which is characterized by an early increase of pulmonary arterial pressure and a decrease of late stage and a significant impact on the prognosis of shock. Our experiments confirmed that endo-toxemia in the early (6h) rat pulmonary artery myoantigen production of peroxynitrite (ONOO-). ONOO- for the rapid non-enzymatic reaction of nitric oxide and superoxide anion