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患者男性,35岁。因偏执型精神分裂症复发于1984年12月22日入院。服氯氮平200～600mg/日治疗。服药期间4次复查血象均正常。1985年2月6日查白细胞7500、中性84%、淋巴16%;出院后继服氯氮平500mg/日治疗。出院后30天患者突然发热(39.1℃),咽痛,扁桃体肿大。次日到某综合医院门诊,查白细胞1150、中性18%、淋巴82%,即停服氯氮平,给利血生、维生素B_4、洁霉素等门诊治疗。后因寒战、持续高热于出院后35天来我院急诊再次入院。检查:体温40.5℃,神萎。左下肢有一3×4cm 疖肿。胸部散在米粒大小暗红色丘疹,巩膜轻度黄染。咽充血。心率136,闻及奔马律和早搏。两肺闻及干罗音。肝肋下1cm,质软,有触痛和叩击痛。脾未触及。
Male patient, 35 years old. Recurrence of paranoid schizophrenia was admitted to hospital on December 22, 1984. Clozapine 200 ~ 600mg / day treatment. 4 times during the medication blood were normal. February 6, 1985 white blood cells checked 7500, 84% neutral, lymph 16%; after discharge of clozapine 500mg / day after treatment. Thirty days after discharge, the patient suddenly fever (39.1 ℃), sore throat, tonsil enlargement. The next day to a general hospital clinic, check white blood cells 1150, 18% neutral, lymphatic 82%, that is, stopping taking clozapine, to Lee blood, vitamin B_4, lincomycin and other outpatient treatment. After the chills, sustained high fever in hospital 35 days after admission to our hospital emergency admission again. Check: body temperature 40.5 ℃, Shen Wei. Left lower extremity has a 3 × 4cm swollen. Chest scattered in the size of dark red papules, scleral mild yellow dye. Pharyngeal congestion. Heart rate 136, smell gallop and premature beat. Two lung smell and dry rales. Liver ribs 1cm, soft, tender and percussion pain. Spleen not touched.