通过自体辅佐细胞(单核或巨噬细胞)提呈处理过的抗原作用于TcR 可激活T 细胞。作用于TcR CD_3复合物的单抗可模拟这种抗原激活效应。作者使用仓鼠抗小鼠单抗145-2 C11,它结合于CD_3复合体上25-KDa的ε链上,从而激活T 细胞增殖。本实验研究了严格去除辅佐细胞的T 细胞在不同浓度培养下,用抗CD_3单抗激活的条件,包括辅佐细胞浓度、二价和多价抗CD_3单抗及细胞因子IL-1、IL-2、IL-6在T 细胞活化增殖 TcR activates T cells by presenting the treated antigen with autologous adjuvant cells (monocytes or macrophages) to TcR. Mabs acting on the TcR CD_3 complex mimic this antigen-activating effect. The authors used the hamster anti-mouse mAb 145-2 C11, which binds to the 25-KDa epsilon chain on the CD3 complex, thereby activating T cell proliferation. In this study, we studied the conditions of activated T cells with different concentrations of anti-CD_3 monoclonal antibodies, including adjuvant cell concentration, bivalent and multivalent anti-CD_3 monoclonal antibodies and cytokines IL-1 and IL-2 , IL-6 in T cell activation and proliferation