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转移性肾癌的治疗目前不太令人满意。作者曾进行过长期应用α—干扰素(α—IFN)的研究,结果表明该治疗方案无持久免疫刺激作用,不能进一步激活自然杀伤细胞系统。为此,本文提出多次短程应用γ—重组人干扰素(γ—rHu—IFN)的治疗方法。 14例系统应用γ—rHu—IFN治疗的患者中,除2例一般情况较差,不宜手术外,余12例已行肾切除术。γ—rHu—IFN的用法为每天肌内注射0.25毫克,共8天。每8天之间的治疗间隔为3～4周。最多用药11个药程。本组有9例可按WHO标准进行疗效评价。结
Treatment of metastatic renal cancer is currently less than satisfactory. The authors have conducted long-term studies using α-IFN. The results show that this treatment regimen does not have long-lasting immune stimulatory effect and can not further activate the natural killer cell system. For this reason, this article proposes several short-term application of γ-recombinant human interferon (γ-rHu-IFN) treatment. Of the 14 patients treated with γ-rHu-IFN system, except for 2 cases which were generally poor and not suitable for surgery, the remaining 12 patients had undergone nephrectomy. The use of γ-rHu-IFN was intramuscular injection of 0.25 mg daily for 8 days. The treatment interval between every 8 days is 3 to 4 weeks. Use up to 11 medications. Nine patients in this group can be evaluated according to the WHO criteria. Knot