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目的探讨产后哺乳大鼠和妊娠大鼠正畸牙移动速率的变化,为临床正畸治疗提供依据。方法选取健康Wistar大鼠50只,其中雌性大鼠45只,6~8周龄分成未妊娠组、妊娠组、哺乳组,雌、雄鼠按2︰1合笼饲养造妊娠、哺乳大鼠模型,每组按7、14、21d时间段正畸牙移动并检测同期骨密度、骨保护素。结果哺乳组胫骨骨密度低于妊娠组低于未妊娠组(P<0.01),差异有统计学意义。哺乳组骨保护素高于妊娠组高于未妊娠组(P<0.05),差异有统计学意义。哺乳组正畸牙移动速率大于妊娠组大于未妊娠组(P<0.05),差异有统计学意义。结论①哺乳大鼠骨密度低于妊娠大鼠,低于未妊娠大鼠。②哺乳大鼠正畸牙移动速率在相同力时明显大于妊娠大鼠及未妊娠大鼠,且于21d最显著。
Objective To investigate the changes of orthodontic tooth movement rate in postpartum lactation and pregnancy rats and provide evidence for clinical orthodontic treatment. Methods Fifty healthy Wistar rats were randomly divided into three groups: 45 female rats, 6-8 weeks old were divided into non-pregnant group, pregnancy group, lactation group, , Each group by 7,14,21d period of orthodontic tooth movement and detect the same period bone mineral density, osteoprotegerin. Results The BMD of tibia in lactation group was lower than that in non-pregnant group (P <0.01), the difference was statistically significant. The level of osteoprotegerin in lactation group was higher than that in non-pregnant group (P <0.05), the difference was statistically significant. The rate of orthodontic tooth movement in lactating group was greater than that in non-pregnant group (P <0.05), the difference was statistically significant. Conclusion ① The bone density of lactating rats is lower than that of pregnant rats and lower than that of non-pregnant rats. ② The rate of orthodontic tooth movement in lactating rats was significantly greater than that in pregnant rats and nonpregnant rats at the same force, and the most significant at 21d.