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70年代末,在动物脑中发现 CCK 样肽类物质的免疫细胞化学证据后不久,有人在羊脑中分离出具有生物活性的8肽 CCK。含 CCK 的神经元已证明存在干新皮层、海马、纹状体、下丘脑和杏仁核等部位。药理学和生化研究表明,CCK 可作为一种神经递质或神经调质,对中脑和额叶前部多巴胺能神经元产生兴奋作用。行为性研究表明,CCK 可对抗强直性昏厥以及对抗由β-内啡肽所导致的镇痛等作用。最近,Flood等发现,经过摄食训练的动物与预先剥夺食物的动物相比较,前者可提高在迷宫回避实验中的返回行为;腹膜内注射8肽 CCK(0.05～1.0μg/kg~(-1))亦具有这种作用。CCK 注射的剂量范围同已知啮齿类动物在进食期间循环血中 CCK 的水平是一致的。剂量(?)反应实验揭示了一种反向的“U”形曲线关系,表明 CCK 是典
Shortly after the discovery of immunocytochemical evidence of CCK-like peptides in the animal brain in the late 1970s, some people have isolated the biologically active 8-peptide CCK in the brain of sheep. CCK-containing neurons have been shown to have dry neocortex, hippocampus, striatum, hypothalamus and amygdala and other parts. Pharmacological and biochemical studies have shown that CCK can be used as a neurotransmitter or neuromodulator to excite dopaminergic neurons in the midbrain and anterior frontal lobes. Behavioral studies have shown that CCK can counteract catalepsy and fight the pain caused by β-endorphin. Recently, Flood et al. Found that compared with the animals deprived of food beforehand, the former improved the return behavior in maze avoidance experiments; and the intraperitoneal injection of the 8-peptide CCK (0.05-1.0 μg / kg -1) ) Also has this effect. The dose range of CCK injections is consistent with the level of CCK circulating blood in known rodents during eating. Dose (?) Reaction experiments revealed an inverted “U” shaped curve indicating that CCK is a canonical