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在西非的塞内加尔和岗比亚,乙型肝炎表面抗原血症检出率在4～8岁儿童中有一高峰,而在这个年龄,热带溃疡和其他渗出性皮肤损害也很常见。为弄清这两者之间的关系,作者于1982年2月在岗比亚Fajara附近一个包扎诊所对其溃疡面大于2×2cm的67例病人进行了研究。方法是:同时采取同一病人的血标本和溃疡面分泌物标本,用反向被动血凝和放射免疫(RIA)方法检测其中的HBsAg,用酶联免疫吸附试验及RIA方法检测HBeAg。结果 5例血清HBsAg阳性病人其溃疡分泌物HBsAg也呈阳性。滴度最高的1例病人,其血清及溃疡分泌物中同时检出HBeAg。12例血清HBsAg阴性病人,其溃疡分泌物也为阴性。它们呈现高度的相关性。
In Senegal and Gambia in West Africa, the detection rate of hepatitis B surface antigenemia has a peak in children 4 to 8 years old, and tropical ulcers and other exudative skin lesions are also common at this age. To clarify the relationship between the two, the authors studied 67 patients whose ulcer surface was greater than 2 × 2 cm at a dressing clinic near Fajara, Gambia in February 1982. Methods: The same patient’s blood samples and ulcer surface secretions samples were taken at the same time, HBsAg was detected by reverse passive hemagglutination and radioimmunoassay (RIA), and HBeAg was detected by enzyme-linked immunosorbent assay and RIA. Results 5 cases of HBsAg-positive patients with ulcer secretions HBsAg also positive. One patient with the highest titer detected HBeAg in both serum and ulcer secretions. 12 cases of serum HBsAg-negative patients, the ulcer secretion is also negative. They show a high degree of relevance.