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目的探讨伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎的应用价值。方法 60例(134颗患牙)重度慢性牙周炎患者作为研究对象,随机分为对照组和观察组,每组30例(67颗患牙)。两组均进行全面专科检查,观察组口服伐昔洛韦治疗,对照组口服安慰剂,48 h后由同一组医师进行手术治疗,并进行超声龈上洁治术、龈下刮治术、根面平整术,常规口腔卫生宣教,2周内0.2%康复新漱口。对比治疗前、术前、4周后,两组实验牙菌斑指数(PLI)、出血指数(BI)、牙周袋探诊深度(PD)、附着丧失(CAL)、龈沟液含量。结果术前观察组BI、GCF低于治疗前及同期对照组(P<0.05),4周后两组患者PLT、BI、PD、GCF均低于治疗前,且观察组低于对照组(P<0.05),观察组CAL低于治疗前及对照组;4周后观察组BI为(2.14±0.57)、PD为(5.54±1.26)mm、GCF为(1.53±1.14)μl,低于术前的(2.68±0.64)、(7.48±0.63)mm、(1.84±1.14)μl,差异具有统计学意义(P<0.05)。结论伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎疗效较好,可增进疗效。
Objective To investigate the application value of valacyclovir in combination with subgingival scaling and root planing in the treatment of severe chronic periodontitis. Methods Sixty patients (134 teeth) with severe chronic periodontitis were randomly divided into control group and observation group with 30 cases (67 teeth). The two groups were comprehensive specialist examination, the observation group oral valacyclovir treatment, the control group oral placebo, 48 h after surgery by the same group of doctors, and ultrasound supragingivalgia, subgingival curettage, root Face flat, conventional oral health education, 0.2% rehabilitation within 2 weeks of new mouthwash. The levels of plaque index (PLI), bleeding index (PD), periodontal pocket probing depth (PD), attachment loss (CAL) and gingival crevicular fluid content were compared between the two groups before and 4 weeks after treatment. Results The levels of BI and GCF in the preoperative observation group were lower than those in the control group (P <0.05), and the PLT, BI, PD and GCF in the two groups were lower than those before treatment and the observation group was lower than the control group (P (P <0.05). The CAL in the observation group was lower than that before treatment and in the control group. After 4 weeks, the BI in the observation group was (2.14 ± 0.57), the PD was (5.54 ± 1.26) mm and the GCF was (1.53 ± 1.14) (2.68 ± 0.64), (7.48 ± 0.63) mm, (1.84 ± 1.14) μl, the difference was statistically significant (P <0.05). Conclusion Valacyclovir combined with subgingival scaling and root-surface treatment of chronic severe periodontitis is better and can improve the curative effect.