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以聚乙烯亚胺为阳离子探针，标记缺铁性贫血患者红细胞表面阴离子位点，透射电镜观察，图象分析仪定量分析。发现患者红细胞阴离子位点密度较正常人者为少，反应减弱，平均灰度伍明显变低。神经氨酸酶处理后阴离子位点少于相应对照组。提示缺铁性贫血患者红细胞表面阴离子位点减少与红细胞的早衰有关。
Polyethyleneimine was used as a cationic probe to label the anions on erythrocytes in patients with iron deficiency anemia. Transmission electron microscopy and image analyzer were used to quantitatively analyze the anions. Found that patients with erythrocyte anion site density less than normal people, the reaction weakened, the average gray level significantly lower. Neuraminidase treatment of anion sites less than the corresponding control group. Tip iron deficiency anemia in patients with reduced erythrocyte surface anion sites associated with premature aging of red blood cells.