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目的:利用实时剪切波弹性成像(shear wave elastography,SWE)定量分析不同睾酮水平阴茎组织硬度之间的差异。方法:睾酮水平不同SD大鼠两组,低睾酮水平组(1月龄,睾酮水平1.00~1.50 ng/m L,n=10)和高睾酮水平组(13月龄,睾酮水平2.00~2.50ng/m L,n=10)。采用放射免疫法测定各组大鼠血清睾酮水平。选用法国Super Sonic Imagine公司生产的Aixplorer超声诊断仪,启动SWE模式对阴茎进行SWE成像并测量其剪切波硬度(shear wave stiffness,SWS)。分析比较两组大鼠血清睾酮水平之间的差异及SWS之间的差异。结果:所有大鼠血清睾酮水平及阴茎组织SWS的测量均成功完成。低睾酮水平组大鼠血清睾酮水平为(1.30±0.16)ng/m L,高睾酮水平组为(2.29±0.14)ng/m L,两组大鼠血清睾酮水平存在显著差异(P<0.01);低睾酮水平组大鼠阴茎组织SWS为(9.86±0.72)k Pa,高睾酮水平组为(7.80±1.43)k Pa,两组大鼠阴茎组织SWS存在显著差异(P<0.01)。结论:SWE可以检测出睾酮水平不同导致的阴茎组织硬度的差异,提示SWE可作为一项评价阴茎组织硬度的无创新技术。
OBJECTIVE: To quantitatively analyze the difference of penis tissue hardness between different testosterone levels by using real-time shear wave elastography (SWE). Methods: The levels of testosterone in two SD rats, low testosterone (1 month old, testosterone 1.00-1.50 ng / m L, n = 10) and high testosterone (13 months old, testosterone 2.00-2.50ng / m L, n = 10). Serum testosterone levels were determined by radioimmunoassay. The Aixplorer ultrasound scanner manufactured by France-based Super Sonic Imagine was used to start the SWE mode to perform penumbral SWE imaging and measure shear wave stiffness (SWS). The difference between serum testosterone levels and SWS was analyzed and compared between two groups. RESULTS: Serum testosterone levels and penile SWS measurements were successfully performed in all rats. The level of serum testosterone was (1.30 ± 0.16) ng / m L in low testosterone group and (2.29 ± 0.14) ng / m L in high testosterone level, there was significant difference between the two groups (P <0.01) The SWS of penile tissue was (9.86 ± 0.72) kPa in low testosterone group and (7.80 ± 1.43) kPa in high testosterone group, there was a significant difference (P <0.01) between the two groups. Conclusion: SWE can detect differences in the hardness of penile tissue caused by different levels of testosterone, suggesting that SWE can be used as a noninvasive technique to evaluate the hardness of penile tissue.