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庆大霉素是临床应用较广泛的抗生素之一，近年来，其肾毒性问题，受到了国内外普遍重视。但庆大霉素所造成的肾毒性往往是亚临床型。为在基层医院减少庆大霉素的肾毒性发生率，我们根据有关资料，对36例患者进行了尿溶菌酶的初步观察。材料与方法随机选择我院内科除泌尿系感染以外的各种感染性疾病44例，对36例选用庆大霉素20万u/日静脉滴注，8例选用除氨基糖甙类以外的抗生素治疗。全部病例于4～14天进行尿溶菌酶测定，在使用庆大霉素的病例中，第4天测定者17例，第5～9天测定者13例，第10～14测定者6例。44例中，男26例，女18例，年龄17～81岁，在进行尿溶菌酶测定的同时，进行尿常规及血尿素氮、肌酐检查。
Gentamicin is one of the more widely used antibiotics in clinical practice. In recent years, its nephrotoxicity has received widespread attention both at home and abroad. However, nephrotoxicity caused by gentamicin is often subclinical. In order to reduce the incidence of gentamicin nephrotoxicity in primary hospitals, we conducted a preliminary observation of urine lysozyme in 36 patients according to the relevant data. Materials and Methods 44 cases of infectious diseases other than urinary tract infection were randomly selected in our hospital. Thirty-six cases were given intravenous drip of 200000u / day of gentamicin and 8 cases of antibiotics other than aminoglycosides treatment. In all cases, urinary lysozyme was measured at 4 to 14 days. In the case of gentamicin, 17 cases were detected on the 4th day, 13 cases were measured on the 5th to 9th days, and 6 cases were detected on the 10th to 14th. 44 cases, 26 males and 18 females, aged 17 to 81 years, urine lysozyme determination at the same time, urine and blood urea nitrogen, creatinine examination.