作者等以1例恶性疟儿童的血液接种枭猴,再通过弗氏按蚊(Anopheles freeborni)人工感染给8名受试者后进行药物治疗试验。该株原虫为巴拿马Ⅱ株。人工感染后,每天涂片检查1次,并做疟原虫计数,在出现原虫或症状后住院观察。每4小时测量体温1次,当体温超过37.8℃时改为每小时1次,直至体温降至正常。采血或原虫计数至少每 The author used a blood sample from a child of falciparum malaria to inoculate Owl’s monkey, which was then artificially inoculated to eight subjects by Anopheles freeborni for drug treatment. The strain protozoan Panama Ⅱ. After artificial infection, smear examination 1 times a day, and do malaria parasite count, in the presence of protozoa or symptoms hospitalized. Body temperature is measured once every 4 hours and changed to 1 hour per hour when body temperature exceeds 37.8 ° C until body temperature falls to normal. Collect blood or protozoa at least per