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为评价99mTc-甲氧基异丁基异腈(MIBI)平面门控心肌显像(EGP)在心肌梗塞患者存活心肌判断中的准确性,对21例心肌梗塞患者进行了静息EGP、静息和运动99mTc-MIBI心肌单光子发射计算机断层(SPECT)显像及饥饿时静息18F-脱氧葡萄糖(FDG)正电于发射计算机断层(PET)显像.在21例患者共105个心肌节段中,有15个节段运动SPECT半定量分析局部99mTc-MIBI放射性分布大于左室峰计数的80%(即正常节段),从本研究中排除.其余90个节段中有77个节段PET显像FDG摄取明显,13个节段无FDG摄取.以FDGPET为标准,EGP在存活心肌判断中的灵敏度和特异性分别为96%和77%,而静息SPECT的灵敏度及特异性分别为96%及69%.两种显像方法在存活心肌判断中差异无显著性,同时两者在心肌节段间计分比较中有良好的一致性(r=0.86).提示EGP在存活心肌判断中与MIBISPECT相似.
To evaluate the accuracy of 99mTc-methoxyisobutylisonitrile (MIBI) planar gated myocardial imaging (EGP) in determining myocardial viability in patients with myocardial infarction, 21 patients with myocardial infarction underwent resting EGP, rest, and exercise 99mTc-MIBI myocardial single photon emission computed tomography (SPECT) imaging and starvation resting 18F-deoxyglucose (FDG) positron emission tomography (PET) imaging. Fifteen of the 21 patients with a total of 105 myocardial segments were excluded from this study by semi-quantitative SPECT semi-quantitative analysis of their 99m Tc-MIBI radioactivity profile greater than 80% of the LV peak count (normal segment). 77 of the remaining 90 segments showed significant FDG uptake in PET imaging and no FDG uptake in 13 segments. With FDGPET as the standard, the sensitivity and specificity of EGP in viable myocardium were 96% and 77%, respectively, whereas the sensitivity and specificity of resting SPECT were 96% and 69%, respectively. There was no significant difference between the two imaging methods in the determination of viable myocardium, and there was a good agreement between the two in the comparison of myocardial segments (r = 0.86). This suggests that EGP is similar to MIBISPECT in determining viable myocardium.