胰腺内注入胰蛋白酶或在过度刺激胰腺分泌之后可观察到胰腺坏死,随后数天可出现类似慢性胰腺炎的表现,但再后数天所有病变包括纤维化均可消失。但亦有不同报道。本文目的是探讨胰管内注射胆汁酸盐人为地造成胰管狭窄是否与持续的慢性病变有关。 材料和方法:雄性Wistar大鼠100只,麻醉后将导管插至胆总管,注入牛磺胆酸钠和胰蛋白酶混合物 Pancreas necrosis is observed after injection of trypsin into the pancreas or after excessive stimulation of pancreatic secretion, followed by chronic pancreatitis over the next few days, but all lesions, including fibrosis, disappear on the next few days. But there are different reports. The purpose of this paper is to investigate whether pancreatic ductal bile acid injection artificially causes pancreatic duct stenosis in association with persistent chronic disease. MATERIALS AND METHODS: One hundred male Wistar rats were anesthetized and catheterized into the common bile duct. Sodium taurocholate and trypsin mixture