重组蛋白A(recombinational protein A)是recA基因的产物,简称recA蛋白,又称X蛋白(protein X)。早在六十年代末就已发现rec基因组并证明它与遗传重组有着密切的关系。1975年,Radman在大肠杆菌中(E.coll)发现了一种新的DNA损伤后的修复系统——“SOS”修复。深入研究表明,这种活动都与rec基因的作用有关,而且都是recA基因产物,即recA蛋白直接作用的结果。后来,许多体内、外的实验证明,此recA蛋白具有极为活跃的生物活性。因此,本文将就recA蛋白及其生物学作用作一简要的综述。 Recombinational protein A is a product of recA gene, referred to as recA protein, also called protein X. The rec genome was discovered back in the late 1960s and proved to be closely related to genetic recombination. In 1975, Radman discovered a new repair system for DNA damage in E.coli called “SOS” repair. In-depth studies have shown that this activity is related to the role of the rec gene, and are recA gene product, the result of the direct effect of recA protein. Later, many in vitro and in vivo experiments demonstrated that this recA protein has extremely active biological activity. Therefore, this article will give a brief overview of recA protein and its biological role.