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本研究评价白细胞介素(IL)-8在有或无败血性休克的脑膜炎球菌脑膜炎和/或菌血症患者中的作用。血清和脑脊液(CSF)标本采自入院时和抗生素治疗前的脑膜炎球菌疾病患者(男32例,女30例)。将病人分为四种类型:有或无菌血症的脑膜炎(30例);败血性休克(11例);脑膜炎和败血性休克(15例);无脑膜炎或休克的菌血症(6例)。还采集7例非细菌性神经疾病患者的CSF。用固相双连接ELISA测定血清和CSF中IL-8水平。
This study evaluated the role of interleukin (IL) -8 in patients with meningococcal meningitis and / or bacteremia with or without septic shock. Serum and cerebrospinal fluid (CSF) specimens were collected from patients with meningococcal disease (32 males and 30 females) on admission and prior to antibiotic treatment. Patients were divided into four groups: meningitis with or without bacteremia (n = 30), septic shock (n = 11), meningitis and septic shock (n = 15), meningitis without meningitis or shock (6 cases). CSF was also collected in 7 patients with non-bacterial neurological disease. IL-8 levels in serum and CSF were measured by solid-phase double-linked ELISA.