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重症肌无力(MG)与多发性肌炎(PM)并存甚少见。我们自1987年7月至1990年5月见到6例同时具有以上两病临床表现及有关辅助检查阳性、并经相应治疗有效的病人,证实为两病并存,报告如下。 例1 女,57岁。因渐进性全身无力、肌疲劳及右大腿肌痛6个月于1989年4月就诊。查:四肢肌力降低,腱反射对称减低,无客观感觉障碍。肌注新斯的明后症状部分好转,血清抗AchRab 0.65nmol/L,CPK2740IU/L,LDH 817IU/L,EMG示肌源性疾病,肌活检为多发性肌炎。用吡啶斯的明及地塞米松治疗后病情迅速缓解。复查血清抗AchRab 0.59nmol/L。
Myasthenia gravis (MG) and polymyositis (PM) co-exist rare. We from July 1987 to May 1990 saw 6 cases of both the clinical manifestations of the above two diseases and related auxiliary examination positive, and the corresponding treatment effective patients, confirmed the coexistence of two diseases, the report is as follows. Example 1 Female, 57 years old. Due to progressive generalized weakness, muscle fatigue and right thigh muscle pain 6 months in April 1989 treatment. Check: lower extremity muscle strength, reduced tendon reflex symmetry, no objective sensory disturbance. After intramuscular injection of neostigmine part of the symptoms improved, serum anti-AchRab 0.65nmol / L, CPK2740IU / L, LDH 817IU / L, EMG showed myogenic disease, muscle biopsy for polymyositis. After treatment with pyridostigmine and dexamethasone, the disease was quickly relieved. Re-examination of serum anti-AchRab 0.59nmol / L.