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目的评价氟哌噻吨-美利曲辛(黛立新)联合盐酸伊托必利治疗功能性消化不良(FD)的效果,探讨治疗FD的有效途径。方法将96例确诊FD并有焦虑、抑郁情绪的患者随机分为治疗组和对照组(n=48),在其他治疗相同的基础上,治疗组予盐酸伊托必利10mg每日3次口服,氟哌噻吨-美利曲辛每日晨口服1片;对照组予盐酸伊托必利口服,4周后症状评估及SDS、SAS评分。结果两组症状均有不同程度的改善,有效率91.7%和54.2%(P<0.05),SDS、SAS评分差异亦有统计学意义(P<0.05)。结论氟哌噻吨-美利曲辛联合盐酸伊托必利可有效缓解FD症状,可用于临床FD的治疗。
Objective To evaluate the efficacy of flupenthixol-melitracin (dextromethorphan) combined with itopride hydrochloride in the treatment of functional dyspepsia (FD) and to explore the effective ways of treating FD. Methods Ninety-six patients with definite FD and anxiety and depression were randomly divided into treatment group and control group (n = 48). On the basis of other treatments, the treatment group was treated with itoprazole hydrochloride 10 mg orally three times per day , Flupenthixol-metyralxin daily oral administration of a tablet; control group to itopride hydrochloride orally, 4 weeks after symptom assessment and SDS, SAS score. Results The symptoms of both groups were improved to some extent. The effective rates were 91.7% and 54.2%, respectively (P <0.05). The differences of SDS and SAS scores were also statistically significant (P <0.05). Conclusion Flupenthixol-melitracen combined with itopride hydrochloride can effectively relieve the symptoms of FD and can be used in the treatment of clinical FD.