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Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry(AMS)based on the HI-13 tandem has been established for biological analysis with ~(26)A1(T_(1/2) = 716,000 years) as the tracer.In this paper,the animal tracing,sample preparation procedure and ~(26)A1-AMS measurement are presented.The sample preparation procedure has been simplified.A high sensitivity of 5×10~(-15) for ~(26)A1/~(27)A1 has been achieved.Two phases were found before and after a break time(t_b)for the ~(26)A1 retained in blood and brain,with t_b≈8 and12 h after the ~(26)Al tracer injection,respectively.
Aluminum is concerned as a possible cause of many diseases. To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food, an accelerator mass spectrometry (AMS) based on the HI-13 tandem has been established for biological analysis with ~ (26) A1 (T_ (1/2) = 716,000 years) as the tracer.In this paper, the animal tracing, sample preparation procedure and ~ (26) A1-AMS measurement are presented. The sample preparation procedure has been simplified. A high sensitivity of 5 × 10 ~ (-15) for ~ (26) A1 / ~ (27) A1 has been achieved.Two phases were found before and after a break time (t_b) for the ~ ) A1 retained in blood and brain, with t_b ≈ 8 and 12 h after the ~ (26) Al tracer injection, respectively.