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目的：对精神分裂症患者在不同阿立哌唑血药浓度下的临床效果进行探讨。方法：选取2014年1月至2015年1月该院所接收精神分裂症患者134例，采用非固定剂量的阿立哌唑分别进行治疗，利用HPLC对患者体内血药浓度进行检测，分别采用阳性、阴性症状量表PANSS对治疗效果进行评价。结果：治疗之后第一、二、三、四周较治疗前相比，PANSS量表总分数、因子分数都明显下降（P＜0.05）。治疗之后的第一、二、三、四周患者血药浓度和剂量呈正相关性（P＜0.05），但与PANSS量表评分并不相关（P＞0.05）。结论：精神分裂症患者不同阿立哌唑血药浓度与临床效果之间无相关性。“,”Objective:To investigate the clinical effect of patients with schizophrenia in different serum concentration of aripiprazole on the spirit.Methods:Choosing 134 schizophrenia patients 2014 January to January 2015 in our hospital,using non fixed doses of aripiprazole in the treatment,the blood drug concentra-tion was detected by HPLC,respectively,using positive and negative symptom scale PANSS of therapeutic effect evaluation.Results:After treatment,the first,two or three and four weeks were significantly lower than those before treatment (PANSS ),the total score and factor scores of P <0.05 were significantly de-creased.After treatment,the first,two or three,four weeks in patients with blood concentration and dose was positively correlated (P0.05).Conclusions:There was no relationship between schizophrenia aripiprazole in patients with different serum concentration and clinical effect.