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目的:观察辨证施治联合核苷(酸)类似物治疗慢性乙肝的疗效及其与外周血调节性T细胞的相关性。方法:收集100例符合抗病毒治疗指征的慢性乙肝患者,分为观察组与对照组,观察组采用中医中药联合核苷(酸)类似物治疗,对照组仅用核苷(酸)类似物治疗,定期观察临床症状、肝功能、HBV-DNA、调节性T细胞等指标,疗程均为1年。结果:观察组与对照组相比,在改善临床症状、缩短肝功能、病毒载量恢复时间等方面经统计学处理有明显差异(P<0.05);观察组治疗后外周血Treg比例明显低于对照组,经统计学处理有明显差异(P<0.05);两组组内比较,治疗后外周血Tregs比例明显降低,经统计学处理有明显差异(P<0.05)。结论:辨证施治联合核苷(酸)类似物能够提高治疗慢性乙肝的疗效,其机理与调节性T细胞有关。
Objective: To observe the therapeutic effect of syndrome differentiation combined with nucleoside (acid) analogues on chronic hepatitis B and its correlation with peripheral blood regulatory T cells. Methods: One hundred patients with chronic hepatitis B who were eligible for antiviral therapy were enrolled and divided into observation group and control group. The observation group was treated with traditional Chinese medicine combined with nucleoside (acid) analogue and the control group only with nucleoside (acid) analogues Treatment, regular observation of clinical symptoms, liver function, HBV-DNA, regulatory T cells and other indicators, treatment for 1 year. Results: Compared with the control group, the observation group had significant difference in the improvement of clinical symptoms, shortening of liver function and recovery time of viral load (P <0.05). The proportion of Treg in the peripheral blood of the observation group was significantly lower than that of the control group There was significant difference between the two groups (P <0.05). The percentage of Tregs in the peripheral blood of the two groups were significantly lower than that in the control group (P <0.05). Conclusion: Syndrome Differentiation combined with nucleoside (acid) analogues can improve the therapeutic effect of chronic hepatitis B, the mechanism of which is related to regulatory T cells.