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胃泌素是胃肠道Ｇ细胞分泌的一种多肽激素，对胃肠道粘膜细胞及某些恶性肿瘤细胞有显著促生长作用，这种作用可被其受体拮抗剂Ｌ－３６５２６０所阻断。本实验用胃泌素－１７及其受体拮抗剂Ｌ－３６５２６０分别或单独对ＢＧＣ－８２３细胞系作用７２ｈ后，发现胃泌素对细胞ｐ５３基因蛋白的表达普遍有促进作用，而Ｌ－３６５２６０对ｐ５３的表达却表现为明显抑制。这一结果提示胃泌素和／或Ｌ－３６５２６０可能参与了细胞的增殖或转化过程。
Gastrin is a polypeptide hormone secreted by G cells of the gastrointestinal tract and has a significant growth-promoting effect on gastrointestinal mucosa cells and certain malignant tumor cells. This effect can be blocked by its receptor antagonist L-365260. . In this experiment, gastrin-17 and its receptor antagonist L-365260 were applied to BGC-823 cell line for 72 hours respectively, and it was found that gastrin generally promoted the expression of p53 protein in cells, and L-365260 The expression of p53 showed obvious inhibition. This result suggests that gastrin and/or L-365260 may be involved in cell proliferation or transformation.