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目的探讨瑞芬太尼复合丙泊酚在小儿先天性唇腭裂修复手术中的应用价值。方法选取小儿先天性唇腭裂修复手术患儿80例,随机分为两组,其中对照组38例,观察组42例,使其各方面均有可比性。对照组患儿给予羟丁酸钠联合氯胺酮麻醉;观察组患儿给予瑞芬太尼联合丙泊酚麻醉。对两组患儿麻醉诱导以后至手术结束时平均动脉压(mean arterial pressure,MAP)及心率进行监测和记录,统计两组患儿术后拔管时间及出手术室时间,以及苏醒期躁动和恶心呕吐发生率。结果麻醉诱导开始以后直至手术结束时,观察组患儿血压和心率均明显低于对照组;观察组患者术后拔管时间以及出手术室时间均明显短于对照组,苏醒期躁动及恶心呕吐等不适发生情况均明显低于对照组。上述比较两组差异有统计学意义(P﹤0.05)。结论对先天性唇腭裂修复手术患儿实施瑞芬太尼复合丙泊酚麻醉只要进行严密观察、注意给药速度并对用量进行适当调整可以具有良好的安全性和可行性。
Objective To investigate the value of remifentanil combined with propofol in the repair of congenital cleft lip and palate in children. Methods Eighty children with congenital cleft lip and palate repair surgery were randomly divided into two groups, 38 cases in control group and 42 cases in observation group, all of which were comparable. The control group was given sodium oxybate combined with ketamine anesthesia; the observation group was given remifentanil combined with propofol anesthesia. The mean arterial pressure (MAP) and heart rate after induction of anesthesia between the two groups were monitored and recorded. The extubation time and operating room time were compared between the two groups, as well as the restless phase Nausea and vomiting. Results After the induction of anesthesia, the blood pressure and heart rate in the observation group were significantly lower than those in the control group after the start of anesthesia induction. The extubation time and operation room time in the observation group were significantly shorter than those in the control group. The recovery period was agitation and nausea and vomiting Discomfort and other conditions were significantly lower than the control group. The difference between the two groups was statistically significant (P <0.05). Conclusions The close observation of remifentanil combined with propofol anesthesia in children with congenital cleft lip and palate repair should pay attention to the speed of drug administration and proper adjustment of the dosage in order to have good safety and feasibility.