Whippie病(WD,肠原性脂肪代谢障碍)报道逐渐增多。自1907年Whipple首次报道后,到1950年仅报道23例,1950～1970年报道126例,而1970～1974年就报道了94例。本文概述WD的临床及组织学发现、病因及发病原理。发展史 Whipple首先报道1例临床表现为消瘦、乏力、脂肪泻及多发性关节炎,病检肠壁及肠系膜淋巴结中有游走性单核巨噬细胞,肠壁固有膜中有棒状菌。特殊染色发现脂肪酸,但无中性脂肪,故提出“肠壁脂质营养障碍”的概念。1950年Hendrix发现充满肠 Whippie’s disease (WD, enteric lipodystrophy) reported gradually increased. After Whipple first reported in 1907, only 23 cases were reported in 1950, 126 cases in 1950-70, and 94 cases in 1970-1974. This article outlines the clinical and histological findings of WD, the etiology and pathogenesis. Whipple first reported the development of clinical manifestations of 1 case of weight loss, fatigue, steatorrhea and multiple arthritis, pathological examination of intestinal wall and mesenteric lymph nodes in migratory macrophages, intestinal wall lamina propria. Special stain found fatty acids, but no neutral fat, it put forward the “intestinal wall lipid nutrition disorders” concept. Hendrix found in 1950 filled with intestines