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目的:研究ZX-5对缺血后视网膜功能的恢复作用,并比较其光学异构体(R,R)-ZX-5和(S,S)-ZX-5对脉络膜血流及缺血后视网膜功能恢复的影响。方法:用彩色微球技术研究兔高眼压下(40mmHg)脉络膜血流的变化。用视网膜电生理仪测量b波,评价大鼠缺血后视网膜功能的恢复情况。结果:10g/L(R,R)-ZX-5滴眼液50μL能在不同时间点提高脉络膜血流(P<0.05),而(S,S)-ZX-5在相同条件下对提高脉络膜血流没有影响。ZX-5和(R,R)-ZX-5在不同时间点对视网膜缺血后功能恢复作用明显(P<0.05),(R,R)-ZX-5的作用优于ZX-5;而(S,S)-ZX-5对缺血后视网膜功能的恢复作用不明显。结论:ZX-5和(R,R)-ZX-5对增加脉络膜血流量和促进视网膜功能的恢复有显著功效,(R,R)-ZX-5恢复视网膜功能的作用更强,有可能进一步开发成有效防治眼血流障碍相关性眼病的药物。
OBJECTIVE: To study the effect of ZX-5 on the recovery of retinal function after ischemia and compare the effects of optical isomers (R, R) -ZX-5 and (S, S) -ZX-5 on choroidal blood flow and ischemia The impact of retinal function recovery. Methods: The changes of choroidal blood flow in rabbits under high intraocular pressure (40 mmHg) were studied by color microspheres technique. The retinal electrophysiology was used to measure the b wave and evaluate the recovery of retinal function after ischemia in rats. Results: 50μL of 10g / L (R, R) -ZX-5 eye drops could improve choroidal blood flow at different time points (P <0.05), while (S, S) -ZX- Blood flow has no effect. The effect of (R, R) -ZX-5 on ZX-5 and (R, R) -ZX-5 was better than ZX-5 after retinal ischemia at different time points (S, S) -ZX-5 on the recovery of ischemic retinal function is not obvious. CONCLUSIONS: ZX-5 and (R, R) -ZX-5 have a significant effect on increasing choroidal blood flow and promoting the recovery of retinal function. The (R, R) -ZX-5 plays a stronger role in the restoration of retinal function and may further Developed into effective prevention and treatment of ocular blood flow disorders related eye disease drugs.