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目的观察替硝唑局部用药治疗牙周病的疗效。方法将35~65岁门诊患者140例,随机分为对照组和观察组,观察组取替硝唑粉剂30g,与适量的淀粉和羧甲机纤维钠研细混匀,加入适量碘甘油制成替硝糊剂,放入器皿中备用。用啄木鸟公司生产的UDS-J型超声洁牙机进行全口洁治,盐水含嗽,隔2d复诊观察,10d一个疗程。对照组口服替硝唑。结果观察组用药后出血,疼痛,肿胀,口臭等症状消失,红肿或肿胀消退,牙周袋深度变浅。X线牙片显示,牙周膜间隙恢复正常,牙槽骨吸收边缘恢复整齐,骨嵴顶端成白线状,骨小梁致密且排列整齐。结论选用替硝唑,因其性能稳定,对革兰氏阳性、阴性,厌氧菌及部分杆菌有较强的杀灭作用,是目前治疗厌氧菌感染的首选药物,尤其对致病厌氧菌有特异性抑制作用,而且他与多数抗生素无配伍禁忌,不引起菌群失调,不诱发迭加感染,不产生耐药菌株,是临床上治疗牙周病的特效药。
Objective To observe the effect of topical tinidazole in the treatment of periodontal disease. Methods 140 outpatients 35 to 65 years old were randomly divided into control group and observation group. The observation group was given 30g tinidazole powder, finely ground with the appropriate amount of starch and carboxymethylcellulose sodium, and added with proper amount of iodine glycerin For nitrite paste, into the vessel spare. Woodpeckers company produced by UDS-J-type ultrasonic scaler full mouth Jieyao, saline cough, 2d visit every 2d, 10d a course of treatment. Control group oral tinidazole. Results After treatment, bleeding, pain, swelling, bad breath and other symptoms disappeared, the swelling and swelling subsided, and the periodontal pocket became shallow. The radiographs of X-ray showed that the periodontal membrane gap returned to normal, the edge of the alveolar bone resumed neatly, the top of the bone ridge became white line, and the trabecular bone was dense and neatly arranged. Conclusion Tinidazole is the best choice for the treatment of anaerobic infections due to its stable properties and strong antimicrobial activity against Gram-positive, negative, anaerobic bacteria and some bacilli, especially for pathogenic anaerobic Bacteria have a specific inhibitory effect, and he is incompatible with most antibiotics incompatibility, does not cause flora, does not induce superimposed infection, does not produce drug-resistant strains, is the clinical treatment of periodontal disease cure.