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目的 观察托毗酯单药治疗成人和儿童各型癫癎的临床效果与安全性。方法 用开放性试验的方法对3４例癫癎患者进行了添加转单药以及首诊单药的托吡酯治疗；以加用托吡酯前３个月的月均发作频率为基准，与单用或转换单用托吡酯进入稳定期后３个月的月均发作频率进行比较，按常规计算发作减少百分比的中位值和有效率百分比。结果：托吡酯无论在添加转单药还是单药的治疗上均有明显疗效，且抗癎谱广，可用于单纯部分性发作有或全面性发作、复杂部分性发作有或全面性发作、婴儿痉挛症，无耐药现象。１４岁以上者托吡酯单药治疗的剂量明显低于添加治疗组。托吡酯的副反应以中枢神经系统最常见，但导致治疗中断的副反应尚未见到。结论 托吡酯是一个广谱抗癫■药，疗效肯定，无耐药性，无严重副反应，可用于单药治疗。
Objective To observe the clinical effect and safety of etoposide monotherapy in the treatment of various types of epilepsy in adults and children. Methods Thirty-four patients with epilepsy were enrolled in this study. Topiramate was administered to patients with epilepsy and the first single dose of topiramate. On the basis of the average monthly frequency of 3 months before topiramate treatment, The monthly mean seizure frequency of topiramate after 3 months of stable phase was compared and the median percentage of seizure reduction and the percentage of effective rate were routinely calculated. Results: Topiramate has obvious curative effect both in the single drug administration and single drug treatment, and the spectrum of antipsychotic spectrum is wide. It can be used in the treatment of simple partial or full-blown episodes, complex partial seizures or generalized seizures. Infantile spasms Symptoms, no resistance. The dose of topiramate monotherapy over the age of 14 was significantly lower than the addition of the treatment group. Side effects of topiramate are the most common in the central nervous system, but side effects leading to treatment interruption have not been seen. Conclusion Topiramate is a broad-spectrum anti-epileptic drug with definite curative effect, no drug resistance, no serious side effects and can be used in monotherapy.