喹唑呋嗪(Prazosin)是一种比较新的抗高血压药物,已使用于肾功能正常的病人。本文报告它与其他抗高血压药联合应用治疗慢性肾衰竭病人的高血压。 12例慢性肾衰竭病人,其中5例为肾移植者。全部病人在对照期和喹唑呋嗪治疗期使用1种或多种其他抗高血压药,如心得安、氯压定、氯噻嗪、速尿和甲基多巴。肾移植者常规使用免疫抑制剂硫唑嘌呤和强的松。7例慢性肾衰竭未作肾移植的病人在使用喹唑呋嗪前作为对照观察期一个月内至少测定2次血压、血尿素、血浆肌酐浓度;对5例肾移植病人在对照观察期每2～3天至少测定2次,因这些病人大多有高血压危象。3例病人开始时要注射氯压定和肼苯哒嗪,以保持舒张压低于120毫米汞柱。在对照观察期后,这些病人加用喹唑呋嗪,开始的剂量为每次1毫克,一日3次。1例病人使用这种剂量1周后发生严 Prazosin is a relatively new antihypertensive drug that has been used in patients with normal renal function. This article reports its use in combination with other antihypertensives in the treatment of hypertension in patients with chronic renal failure. Of 12 patients with chronic renal failure, 5 were renal transplant recipients. All patients received one or more other antihypertensives such as propranolol, clonidine, chlorothiazide, furosemide, and methyldopa during the control period and the quzadoxazine treatment period. Kidney transplant routine use of immunosuppressive agents azathioprine and prednisone. Seven patients without renal transplantation for chronic renal failure were treated with quzofurizine for at least 2 times of blood pressure, blood urea nitrogen and plasma creatinine concentration within one month before the observation period. ~ 3 days at least 2 times, because most of these patients have hypertensive crisis. Three patients initially received clonidine and hydralazine to maintain diastolic blood pressure below 120 mmHg. After the control period, these patients treated with carbachofen and started a dose of 1 mg each time three times a day. One patient developed stricture after 1 week of use of this dose