多发性硬化(MS)中脑白质损害是病变的首要部位,但尸检显示脑灰质亦常被累及。在MS中,继发于脑白质损害的脑灰质神经元退行性改变可能是由灰质的病理性异常造成的。病灶较小、弛豫特性以及CSF部分容积效应影响常使灰质病灶在T_2像上被遗漏。尽管FLAIR对灰质病灶检测敏感性高于T_2加权像,但仍有其局限性。本研究采用扩散张量成像对好转复发型(RRMS)、继发进展型(SPMS)、原发进展型(PPMS)的MS病人的脑灰质病理异常改变的程度进行活体定量检测。 White matter lesions of multiple sclerosis (MS) are the primary site of disease, but autopsy shows that gray matter is also frequently involved. In MS, degenerative changes of gray matter neurons secondary to white matter damage may be caused by pathological abnormalities of gray matter. Smaller lesions, relaxation characteristics and volume effects of CSF often cause gray matter lesions in the T_2 image is missing. Although FLAIR is more sensitive to the detection of gray matter lesions than to T_2-weighted images, it has its limitations. In this study, diffusion tensor imaging was used to quantitatively detect the degree of gray matter pathological changes in MS patients with RRMS, SPMS, and PPMS.