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口腔扁平苔藓(OLP)是口腔黏膜疾病中具有代表性的一种自身免疫性疾病,其病因依然不明确,自身抗原的异常表达和识别被认为可能是引发疾病的一大原因。树突状细胞是抗原提呈能力最强的细胞,是激活T细胞免疫的主要途径。在OLP中,树突状细胞的数量明显增加,其类型也与正常黏膜组织中有所差异;其趋化因子受体的表达表现出活化的功能状态;其识别抗原的Toll样受体在OLP组织中也有明显的差异表达。本文就树突状细胞在OLP中的亚群/生物标记物、趋化因子表达、Toll样受体表达等方向的研究现状做一综述。
Oral lichen planus (OLP) is an autoimmune disease in oral mucosal disease. Its etiology is still not clear. Abnormal expression and recognition of autoantigen are considered to be a major cause of disease. Dendritic cells are the strongest antigen presenting cells, is the main way to activate T cell immunity. In OLP, the number of dendritic cells was significantly increased, and its type is also different from normal mucosal tissue; its chemokine receptor expression shows the functional status of activation; its antigen-recognizing Toll-like receptors in the OLP There are also obvious differences in the expression of the organization. This review summarizes the research status of dendritic cells in subpopulation / biomarker, chemokine expression and Toll-like receptor expression in OLP.