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已知雌激素特别是雌二醇(E_2)可以通过各种途径影响间质细胞产生睾酮(T)的量。首先,E_2可抑制男子的下丘脑释放黄体生成素(LH),卵泡刺激素(FSH),而使间质细胞分泌 T 量减少。其次,在体内和体外实验 E_2可直接抑制间质细胞分泌雄激素。睾丸功能异常男子是否与睾丸中 E_2水平升高有关?本文作者对生殖功能障碍的男子的血清及睾丸中 E_2水平与生殖功能的关系进行了研究。研究包括48例睾丸体积>10ml,精液容量和果糖浓度正常,无精子或精子缺乏的男子。在局麻下行睾丸活检,活检材料部分固定包埋后作组织切片,观察曲精细管管壁纤维化程度,浅染和深染的
Estrogen, especially estradiol (E2), is known to affect the amount of testosterone (T) produced by stromal cells in a variety of ways. First of all, E 2 inhibits the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the hypothalamus of men and reduces the amount of T secreted by interstitial cells. Second, in vitro and in vivo experiments E_2 can directly inhibit the secretion of interstitial cells androgen. Is Testicular Abnormalities Associated with Elevated E_2 in Testis? The authors studied the relationship between E 2 levels and reproductive function in the serum and testis of reproductive-dysfunctional men. The study included 48 men whose testes volume was> 10 ml and whose sperm volume and fructose concentrations were normal and lack of sperm or sperm. Under local anesthesia testis biopsy, biopsy material after part of fixed embedding for the tissue section, observe the curvature of the fine tube wall fibrosis, light and dark stained