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目的评价奥沙利铂(L-OHP)联合氟尿嘧啶(5-FU)治疗晚期胃癌的近期疗效和毒性反应。方法 31例晚期胃癌患者给改良方案奥沙利铂100mg/m2加5%葡萄糖500ml静滴4小时,d1天;亚叶酸钙200mg/m2加0.9%生理盐水250ml静滴2小时,完成后即给予静推氟尿嘧啶500mg,氟尿嘧啶2.5g持续静滴48小时,每两周重复。结果共治31例,CR1例,PR16例,SD9例,PD5例,总有效率54.8%。主要反应为骨髓抑制、恶心呕吐、轻度的外周神经毒性。结论奥沙利铂联合持续静滴氟尿嘧啶治疗晚期胃癌疗效确切,不良反应轻,患者耐受性好。
Objective To evaluate the short-term curative effect and toxicity of oxaliplatin (L-OHP) combined with 5-fluorouracil (5-FU) in the treatment of advanced gastric cancer. Methods 31 cases of advanced gastric cancer patients to the improved program oxaliplatin 100mg / m2 plus 5% glucose 500ml intravenous infusion of 4 hours, d1 days; leucovorin 200mg / m2 plus 0.9% saline 250ml intravenous infusion of 2 hours after the completion of that given Pushed fluorouracil 500mg, 2.5g fluorouracil continued intravenous 48 hours, repeated every two weeks. Results A total of 31 cases were treated, CR1 cases, PR16 cases, SD9 cases, PD5 cases, the total effective rate was 54.8%. The main reaction is myelosuppression, nausea and vomiting, mild peripheral neurotoxicity. Conclusion Oxaliplatin combined with continuous infusion of fluorouracil for the treatment of advanced gastric cancer has definite curative effect, mild adverse reactions and good patient tolerance.