自从本世纪初以来,生物化学家就开始了肿瘤生化病理学的研究,并致力于寻找肿瘤标志物,提出了许多解释细胞癌变的生化假说。如20年代Warburg提出肿瘤细胞的呼吸机构不可逆损伤假说(warburg hypothesis),40年代Miller夫妇提出蛋白质丢失假说(deletion hypothesis),50年代 Since the beginning of this century, biochemists have begun research on the biochemical pathology of tumors and have devoted themselves to the search for tumor markers. Many biochemical hypotheses have been proposed to explain the canceration of cells. For example, in the 1920s, Warburg proposed a warburg hypothesis for the respiratory cells of cancer cells. In the 1940s Miller and his colleagues proposed a hypothesis for protein loss (deletion hypothesis).