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目的探讨新疆地区汉族、维族帕金森病(PD)患病的危险因素。方法选取2008年～2010年新疆部分三级医院确诊的PD患者262例,汉族159例,维族103例,同时选取健康对照组做病例对照研究。结果条件logistic回归分析显示,汉族非喝茶者患PD的危险性是喝茶者的4.7倍[Exp(B)分别为0.21],非吸烟者患PD的危险性是吸烟者的2.8倍[Exp(B)=0.35];农药接触史者患PD的危险性是非农药接触史者的1.42倍,重大精神创伤史者患PD的危险性是非重大精神创伤史者的16.16倍。维族非喝茶者患PD的危险性是喝茶者2.1倍[Exp(B)=0.47];农药接触史者患PD的危险性是非农药接触史者4.62倍。结论喝茶是PD的保护因素,农药接触史是PD的危险因素。汉族配对研究中,吸烟、饮用井水、高血压病史具有保护作用,重大精神创伤史是PD的危险因素。
Objective To investigate the risk factors of Parkinson’s disease (PD) in Han and Uygur nationality in Xinjiang. Methods A total of 262 PD patients, 159 Han patients and 103 Uygur patients diagnosed in some tertiary hospitals in Xinjiang from 2008 to 2010 were selected. A case-control study was also conducted on healthy controls. RESULTS: Logistic regression analysis showed that the risk of PD in non-drinkers of Han nationality was 4.7 times than that of tea drinkers (Exp (B), respectively, 0.21), and that of non-smokers was 2.8 times of that of smokers [Exp (B) = 0.35]. The risk of PD in the history of pesticide exposure was 1.42 times of the history of non-pesticide exposure. The risk of PD in patients with major trauma was 16.16 times higher than that in non-major trauma patients. The risk of PD in Uygur tea drinkers was 2.1 times that of tea drinkers [Exp (B) = 0.47]. The risk of PD in the history of pesticide exposure was 4.62 times of the non-pesticide exposure history. Conclusion Tea is the protective factor of PD, and the history of pesticide exposure is a risk factor for PD. Han pairing research, smoking, drinking well water, history of hypertension has a protective effect, a history of major trauma is a risk factor for PD.