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目的观察不同年龄组人的螺旋神经节细胞形态变化，进行定量研究。方法用火棉胶及脱火棉胶人的颞骨切片观察螺旋神经节及其脂褐素，进行图像分析测定。结果随年龄增长螺旋神经节细胞逐渐减少，由０～９岁组的３９２９３个减少至８０～８８岁组的１６７８１个，自２０岁组开始至８０～８８岁组与０～９岁组比较差异有显著性（Ｐ＜０．０５或０．０１）。老年组不仅螺旋神经节细胞明显减少、细胞大小不等、核浓缩或淡染、核偏移，而且耳蜗神经纤维也减少，但胶质细胞增生。随着增龄脂褐素沉积逐渐增多。结论老年人螺旋神经节细胞减少，细胞质内脂褐素沉积，可能是导致老年性耳聋的主要原因之一。
Objective To observe the morphological changes of spiral ganglion cells in different age groups and conduct quantitative research. Methods Pancreatic ganglion and its lipofuscin were observed with the human temporal bone slices of collodion and abscisic acid. The image analysis was performed. Results The number of spiral ganglion cells gradually decreased with age, from 39293 in 0-9 years old group to 16781 in 80-88 years old group, from 20 years old group to 80-88 years old group and 0-9 years old group Significant (P <0.05 or 0.01). In the aged group, the number of spiral ganglion cells was significantly decreased, the cell size was different, the nuclei were concentrated or lightly stained, the nucleus was shifted, and the cochlear nerve fibers were also reduced, but glial cells proliferated. As the age of lipofuscin deposition gradually increased. Conclusion The decrease of spiral ganglion cells and the deposition of lipofuscin in the cytoplasm may be one of the main causes of senile deafness.