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目的探讨(125)~Ⅰ放射性粒子在肝癌小病灶中应用的安全性、可行性及初步效果。方法 11例肝癌患者肝内15处小病灶(直径<3 cm)在B超或CT导向下经过穿刺途径植入(125)~Ⅰ放射性粒子,术后1～3 d行SPECT检察评价粒子植入情况,CT随访评价病灶治疗效果,随访1～7个月。结果所有病灶均成功植入(125)~Ⅰ放射性粒子,1～10粒/病灶,共计110粒,患者未出现出血、感染、贫血等严重并发症:术后1～3 d行SPECT检查,证实(125)~Ⅰ放射性粒子均植入靶病灶,无体内移位,γ射线覆盖病灶完全;1个月后CT随访,靶病灶均明显变小。结论肝癌小病灶在超声或CT导向下经穿刺途径植入(125)~Ⅰ放射性粒子安全可行,靶病灶明显变小:(125)~Ⅰ放射性粒子植入是治疗肝癌小病灶的一种有效方法,可作为肝癌综合治疗方案中的一个选择。
Objective To investigate the safety, feasibility and preliminary effect of (125) ~ Ⅰ radioactive particles in small lesions of liver cancer. Methods Totally 11 small intrahepatic lesions (diameter <3 cm) were implanted with radioactive particles 125 (125 Ⅰ-Ⅰ) under the guidance of ultrasound or B-mode ultrasound in 11 patients with liver cancer. SPECT was used to evaluate the effect of particle implantation Condition, CT follow-up evaluation of lesions treatment, follow-up of 1 to 7 months. Results All the lesions were successfully implanted with radioactive particles (125 ~ Ⅰ), 1-10 particles / lesions, totaling 110 particles. No serious complications such as hemorrhage, infection and anemia were observed. SPECT examination was performed 1-3 days after operation (125) ~ Ⅰ radioactive particles were implanted into the target lesion, no in vivo displacement, γ ray coverage lesions complete; 1 month after CT follow-up, target lesions were significantly smaller. Conclusion It is safe and feasible to implant (125) ~ Ⅰ radioactive particles through the puncture pathway under the guidance of ultrasound or CT with small lesions of liver cancer. The target lesion is obviously smaller: (125) ~ Ⅰ radioactive seeds implantation is an effective method for the treatment of small lesions of liver cancer , Can be used as a comprehensive treatment of liver cancer in an option.