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目的观察尼可地尔对经皮冠状动脉介入(PCI)术后心绞痛患者的疗效,探讨其对丙二醛(MDA)与脂联素(APN)水平的影响。方法将延安大学附属医院心脑血管病分院2013年1月至2015年1月收治的180例PCI术后心绞痛患者随机分为两组,对照组(90例)采用常规治疗,观察组(90例)在此基础上口服尼可地尔。比较两组疗效和患者MDA与APN水平。结果观察组患者治疗有效率为96.7%,对照组为81.1%,两组差异有统计学意义(P<0.05)。治疗后,两组心绞痛发作次数均较治疗前显著降低(P<0.05),观察组治疗后心绞痛状况优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的硝酸甘油用量均较治疗前显著降低(P<0.05),观察组治疗后的硝酸甘油用量显著少于对照组(P<0.05)。两组患者治疗后的MDA、总胆固醇、三酰甘油和低密度脂蛋白水平均较治疗前显著降低(P<0.05),观察组治疗后的各项指标均优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的APN均较治疗前显著升高(P<0.05),且观察组高于对照组,差异有统计学意义(P<0.05)。治疗期间,观察组患者共出现3例腹胀、恶心,对照组患者出现2例面红、头痛,两组差异无统计学意义(P>0.05)。结论 PCI术后心绞痛的患者应用尼可地尔能够有效改善心绞痛症状,减轻心肌损伤,改善预后。
Objective To observe the effect of nicorandil on patients with angina pectoris after percutaneous coronary intervention (PCI), and to investigate its effect on malondialdehyde (MDA) and adiponectin (APN) levels. Methods 180 cases of angina pectoris patients admitted from January 2013 to January 2015 in the Department of Cardiology and Cerebrovascular Diseases, Affiliated Hospital of Yan’an University were randomly divided into two groups. The control group (90 cases) was treated by conventional therapy. The observation group (90 cases Based on this, Nicorandil was orally administered. The efficacy and the level of MDA and APN were compared between the two groups. Results The effective rate of treatment was 96.7% in observation group and 81.1% in control group, the difference was statistically significant (P <0.05). After treatment, the number of angina pectoris in both groups was significantly lower than that before treatment (P <0.05). The angina pectoris condition in the observation group was better than that in the control group. The difference was statistically significant (P <0.05). The amount of nitroglycerin in both groups after treatment was significantly lower than that before treatment (P <0.05), and the dosage of nitroglycerin in the observation group was significantly less than that of the control group (P <0.05). After treatment, the levels of MDA, total cholesterol, triglyceride and low density lipoprotein in both groups were significantly lower than those before treatment (P <0.05). The indexes in the observation group were better than those in the control group after treatment Significance (P <0.05). APN in both groups after treatment was significantly higher than before treatment (P <0.05), and the observation group was higher than the control group, the difference was statistically significant (P <0.05). During the treatment period, there were 3 cases of bloating and nausea in the observation group, and 2 cases of redness and headache in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion The use of nicorandil in patients with angina after PCI can effectively improve the symptoms of angina pectoris, reduce myocardial damage and improve prognosis.