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为了探讨胆管癌的病理学特征对其预后的影响，提高外科治疗的远期效果，我们在总结手术治疗１０３例肝门部胆管癌的基础上，对７２例有病理诊断者进行了回顾分析；并重新对７８例肝外胆管癌的石蜡包埋标本，进行Ｋｉ－６７核蛋白表达的研究。结果显示：肝门部胆管癌的病理分化程度越低胆管癌对周围神经、脂肪组织的浸润及淋巴结转移率越高，预后较差的中低分化及粘液腺癌所占的比例高达４７．２％，手术后长期生存者均为高分化腺癌。并发现胆管癌不同组织类型与分化程度与Ｋｉ－６７核蛋白表达呈明显的相关性，即分化程度越差Ｋｉ－６７核蛋白表达越强。结论提示：胆管癌的病理组织类型对预后有明显影响；ｋｉ－６７核蛋白表达可为判定胆管癌恶性程度及预后的指标
To explore the effect of pathological features of cholangiocarcinoma on its prognosis and to improve the long-term outcome of surgical treatment, we reviewed the results of surgical treatment of 103 cases of hilar cholangiocarcinoma and retrospectively analyzed 72 cases with pathological diagnosis. The paraffin-embedded specimens of 78 cases of extrahepatic cholangiocarcinoma were performed again to study the expression of Ki-67 nuclear protein. The results showed that the lower the degree of pathological differentiation of hilar cholangiocarcinoma, the higher the rate of infiltration and lymph node metastasis of peripheral nerves and adipose tissue of cholangiocarcinoma was, and the proportion of poorly differentiated and poorly differentiated and mucinous adenocarcinomas was as high as 47.2. %, long-term survivors after surgery are well-differentiated adenocarcinomas. It was found that different tissue types and differentiation of cholangiocarcinoma were significantly correlated with the expression of Ki-67 nuclear protein, that is, the worse the differentiation, the stronger the expression of Ki-67 nuclear protein. Conclusion: The pathological type of cholangiocarcinoma has a significant impact on prognosis; ki-67 nuclear protein expression can be used to determine the degree of malignancy and prognosis of cholangiocarcinoma