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本文研究了注射外源性雌激素(10微克/10克体重/天,共14天)和摘除卵巢(35天)对淋巴组织和淋巴细胞的影响。注射雌二醇组动物的胸腺和脾脏重量,两者中的ANAE(+)细胞百分率,外周血液中的白细胞总数、淋巴细胞绝对值、淋巴细胞中的ANAE(+)细胞的百分率及其绝对值以及胸腺和脾脏细胞内的cAMP水平均显著降低。摘除卵巢组动物的胸腺重量显著增大;胸腺细胞、脾细胞和外周血淋巴细胞中的ANAE(+)细胞的百分率显著降低;以及脾脏细胞内的cAMP水平显著降低。
This article investigates the effects of exogenous estrogen (10 μg / 10 g body weight / day for 14 days) and ovariectomy (35 days) on lymphoid tissues and lymphocytes. Thymus and spleen weights of animals injected with estradiol, the percentage of ANAE (+) cells in both, the total number of leukocytes in peripheral blood, the absolute value of lymphocytes, the percentage of ANAE (+) cells in lymphocytes and their absolute values As well as cAMP levels in thymus and spleen cells were significantly reduced. Thymus weight was significantly increased in ovariectomized animals; the percentage of ANAE (+) cells in thymocytes, splenocytes and peripheral blood lymphocytes was significantly reduced; and cAMP levels in spleen cells were significantly reduced.