白血病是儿童期恶性肿瘤的最常见形式,其发病率可达4/10万,占15岁以下儿童肿瘤患者的30%。在儿童白血病中,急性淋巴细胞白血病(ALL)占78%,且在发达国家,儿童 ALL 发病年龄高峰为2～5岁。研究发现,儿童ALL 的总发病率在不同的国家和地区差异很大,可相差10倍,即在包括美国在内的发达国家发病率明显高于发展中国家,认为与工业化相关的环境因素可能是发病率不同的 Leukemia is the most common form of childhood malignancy with a prevalence of up to 40,000, accounting for 30% of children under 15 years of age. In childhood leukemia, acute lymphoblastic leukemia (ALL) accounts for 78%, and in developed countries, the peak age of ALL children is 2 to 5 years old. The study found that the overall incidence of ALL in children in different countries and regions vary greatly, a difference of 10 times, that in developed countries, including the United States, the incidence was significantly higher than that of developing countries, that industrialization-related environmental factors may The incidence is different