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目的：探讨巴曲抗栓酶（ｂａｔｒｏｘｏｂｉｎ，ＤＦ－５２１）治疗难治性肾病综合征１７例，男性１０例，女性７例，年龄２２±ｓ４ａ。用巴曲抗栓酶溶于０．９％氯化钠液２５０ｍＬ中静脉滴注，首次剂量１０ＢＵ，维持剂量５ＢＵ，隔日１次，共３次。结果：２个疗程（２个疗程间隔１ｗｋ），完全缓解占６５％，总有效率９４％。６５％的病人尿蛋白转阴，血液流变学指标恢复正常，疗效巩固，缓解超过３ｍｏ。治疗期间未发现任何不良反应。结论：巴曲抗栓酶治疗难治性肾病综合征是安全和有效的
Objective: To investigate the effect of batroxobin (DF-521) on 17 refractory nephrotic syndromes, including 10 males and 7 females, aged 22 ± s4a. Batroxobin dissolved in 0.9% sodium chloride solution 250mL intravenous infusion, the first dose of 10BU, to maintain the dose of 5BU, every other day, a total of 3 times. Results: 2 courses (2 courses interval 1wk), complete remission accounted for 65%, the total effective rate 94%. 65% of patients urinary protein negative, blood rheology indicators returned to normal, the effect of consolidation, ease more than 3mo. During the treatment did not find any adverse reactions. Conclusion: Batroxobin is a safe and effective treatment for refractory nephrotic syndrome