溴化钾咖啡因合剂(巴氏合剂)是常用的内服制剂.因含有溴化钾,能被微生物用来维持生命,配制时若不加防腐剂,在贮存过程中极易引起微生物的生长繁殖。为此,我们进行了防腐剂的选择试验,将液体制剂常用的防腐剂尼泊金乙酯、苯甲酸纳等与加入适量柠檬酸作比较,从中选出较理想的防腐剂,以保证制剂的质量. Potassium bromide caffeine mixture (pasteurized) is a commonly used oral preparation.Because potassium bromide, can be used by microorganisms to maintain life, if formulated without preservatives, can easily lead to microbial growth and reproduction during storage . To this end, we conducted a selection test of preservatives, liquid formulations commonly used preservatives such as ethylparaben, sodium benzoate and so on with the appropriate amount of citric acid compared to choose the more ideal preservative to ensure the preparation of quality.