目的 :总结皮层下动脉硬化性脑病 (SAE)临床、影像学表现及诊断要点。方法 :收集分析临床资料完整并有 CT扫描的病例 330例 ,其中 5 4例加磁共振成像。结果 :进行性智能障碍是 SAE的主要临床表现 ,CT扫描显示脑内白质区多发低信号灶 ,MRI表现为长 T1 、长 T2 异常信号灶 ,同时合并多发腔隙性脑梗塞和脑萎缩。结论 :CT平扫结合临床是 SAE最简便有效的诊断手段 ,MRI能更敏感地显示合并的脑内细小梗塞灶 Objective: To summarize the clinical and imaging findings and diagnosis points of subcortical arteriosclerotic encephalopathy (SAE). Methods: The clinical data were collected and analyzed in 330 patients with complete CT scan, including 54 cases with MR imaging. Results: Progressive dysfunction was the main clinical manifestation of SAE. CT scan showed multiple low signal lesions in the white matter area of ​​the brain. MRI showed long T1 and long T2 abnormal signal lesions with multiple lacunar infarcts and brain atrophy. Conclusion: CT combined with clinical diagnosis of SAE is the most simple and effective diagnostic tool, MRI can be more sensitive to show the combined brain infarction