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澳大利亚 Mercer 等研究了牛卵泡液抑素对母羊(下丘脑和垂体间中断及卵巢已切除)垂体 LH 和 FSHβ、α亚基以及 PRL 等的 mRNA 浓度的影响。实验母羊预先给予 GnRH 脉冲,每2h 一次,共给一周,以维持垂体的功能。动物给予牛卵泡液(2ml/只)6h 后(牛卵泡液每 ml 相当于9～18kU 抑素),垂体 FSHβmRNA浓度下降约80%,同时血浆 FSH 浓度仅下降8%,30h 后,血浆 FSH 浓度下降50%时,垂体 FSHβmRNA浓度下降90%之多。说明抑素选择性地降低 FSHβ基因表达水平,而并不是简单地抑制 FSH 从垂体释放。
Australian Mercer et al. Studied the effects of bovine follicle-stimulating hormone on mRNA levels of LH and FSHβ, α subunits and PRL in ewes (hypothalamus and pituitary breaks and ovariectomized). Experimental ewes pre-given GnRH pulse, once every 2h, a total of one week to maintain the function of the pituitary gland. Animal bovine follicular fluid (2ml / only) after 6h (bovine follicular fluid equivalent to 9 ~ 18kU per ml of somatostatin), pituitary FSHβmRNA concentration decreased by about 80%, while plasma FSH concentration decreased only 8%, 30h after plasma FSH concentration A 50% decrease in pituitary FSHβ mRNA levels decreased by as much as 90%. Indicating that somatostatin selectively reduces FSHβ gene expression, but not simply inhibit FSH release from the pituitary.