在内毒素休克、低血容量性休克和脊髓损伤性休克等病理状态下,血浆中内源性阿片肽含量增高。内源性阿片肽具有降低血压、减慢心率和呼吸的作用,而阿片肽受体特异性拮抗剂——纳洛酮可能有抗休克作用。本文利用抗原—抗体特异性结合的原理,在动物烫伤后立即尾静脉注射抗强啡肽 A 血清,以中和循环中升高的强啡肽 A,观察烫伤动物存活时间及血压、心率和心电图的变化,以及下血脑视上核及室旁核神经 In endotoxin shock, hypovolemic shock and spinal cord injury shock and other pathological conditions, plasma endogenous opioid peptide levels increased. Endogenous opioid peptides have the effect of lowering blood pressure, slowing down the heart rate and respiration, and naloxone, an opioid receptor-specific antagonist, may have an anti-shock effect. In this paper, anti-dynorphin A serum was injected into the caudal vein immediately after scald to neutralize elevated dynorphin A in scalded animals. The survival time, blood pressure, heart rate and electrocardiogram Changes, as well as the lower supraoptic nucleus and paraventricular nucleus nerves