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近年来,随着有关睡眠期的通气和呼吸调节的基础理论和临床研究的不断进展,提出并系统地阐述了“睡眠呼吸暂停综合征”(Sleep apnea syndrome)的概念。逐渐认识到睡眠期的呼吸异常可能同慢性阻塞性肺疾患、肺心病等多种疾病的发生与发展有一定的关系。 睡眠期呼吸异常研究的概况 1956年 Burwell等首先提出“Pickwickian综合征”,它的主要表现是高度肥胖,过度嗜睡、肺泡通气不足、红细胞增多和肺心病。这种病人无气道和肺部疾患,因而其肺泡通气不足的原因引起了肺生理学家、心脏病学家和神经病理学家的密切注意和广泛研究。当初,高度肥胖被认为是此综合征的主要病因,却又
In recent years, along with the continuous advancement of basic theory and clinical researches on ventilation and respiratory regulation during sleep, the concept of “sleep apnea syndrome” has been proposed and systematically described. It is gradually realized that the abnormal breathing during sleep may be related to the occurrence and development of many diseases such as chronic obstructive pulmonary disease and pulmonary heart disease. In 1956, Burwell et al. First proposed “Pickwickian syndrome”. Its main manifestations are hyper-obesity, excessive sleepiness, insufficient alveolar hypoventilation, increased red blood cells and pulmonary heart disease. The reason that such patients have no airway and lung disorders and therefore their lack of alveolar hypoventilation has drawn close attention and extensive research by pulmonary physiologists, cardiologists and neuropathologists. Initially, a high degree of obesity is considered the main cause of this syndrome, but again