论文部分内容阅读
目的 测定三叶因子1(trefoil factor,TFF1)在正常、功能性消化不良、慢性胃炎胃粘膜中的表达情况,探讨TFF1与功能性消化不良和慢性胃炎的关系。方法 应用免疫组化方法测定正常人和功能性消化不良、慢性胃炎患者胃窦黏膜中TFF1的表达,通过图像分析软件分析其阳性信号平均光密度值。结果 慢性胃炎组TFF1的表达明显高于正常组和功能性消化不良组,而正常组和功能性消化不良组中表达均较弱,二者统计学上无差异。结论 TFF1在正常组和功能性消化不良组中表达相似,认为TFF1与功能性消化不良的发病无关:而慢性胃炎组表达较高,认为与TFF1在胃黏膜屏障功能保护和促进上皮重建的机制有关。
Objective To determine the expression of trefoil factor 1 (TFF1) in gastric mucosa of patients with normal and functional dyspepsia and chronic gastritis and to explore the relationship between TFF1 and functional dyspepsia and chronic gastritis. Methods Immunohistochemical method was used to determine the expression of TFF1 in antral mucosa of patients with functional dyspepsia and chronic gastritis. The average optical density of positive signals was analyzed by image analysis software. Results The expression of TFF1 in chronic gastritis group was significantly higher than that in normal group and functional dyspepsia group, but not in normal group and functional dyspepsia group. There was no statistical difference between the two groups. Conclusions TFF1 is similar in normal group and functional dyspepsia group. TFF1 is not associated with functional dyspepsia, while chronic gastritis group is highly expressed, suggesting that TFF1 may be involved in the protective function of gastric mucosal barrier and the mechanism of promoting epithelial remodeling. .