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目的 了解混配农药中氰戊菊酯在小鼠体内的代谢和分布。方法 以14 C -氰戊菊酯为示踪剂 ,静脉注射给药。给药后 0 .5～ 12 0min之间采 9次血样 ,8～ 96 0min之间分别对脑、心脏、肝脏和肺脏采 8次样品。样品用 β闪烁计数仪测量 ,并换算成化学浓度。用残数法计算毒代动力学参数。结果 混配农药中的氰戊菊酯的代谢符合二室开放模型。分布相T1/ 2 α为 2 .7min ,消除相T1/ 2 β为 10 6 .6min ,表观分布容积为 2 .9L/kg ,正向扩散系数k12 (0 .17min-1)大于逆向扩散系数k2 1(0 .0 77min-1)。分布浓度肺脏中最高 ,其次为肝脏、心脏、脑。结论 肺脏优势参与了氰戊菊酯的代谢过程 ,应重视此类农药的肺脏毒性。
Objective To understand the metabolism and distribution of fenvalerate in mice with mixed pesticides. Methods 14 C - fenvalerate as tracer, administered intravenously. Nine times blood samples were taken between 0. 5 and 12 0 minutes after drug administration, and 8 samples were collected from brain, heart, liver and lung respectively between 8 and 96 minutes. Samples were measured with a beta scintillation counter and converted to chemical concentrations. Toxicokinetic parameters were calculated using the residual method. Results The metabolism of fenvalerate in the mixed pesticides conformed to the two-compartment open model. The distribution phase T1 / 2 α was 2.7 min, the elimination phase T1 / 2 β was 106.6 min, the apparent volume of distribution was 2.9L / kg, the positive diffusion coefficient k12 (0.17min-1) was larger than the inverse diffusion coefficient k2 1 (0 .0 77min-1). Distribution of the highest concentration in the lungs, followed by the liver, heart, brain. Conclusions The advantage of lung is involved in the metabolism of fenvalerate. The lung toxicity of these pesticides should be emphasized.