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目的检测采自广东省湛江市区的褐家鼠对第一代抗凝血灭鼠剂的抗性发生水平。方法将捕自湛江市的褐家鼠在室内预试验一段时间后,对合格试鼠采用无选择性摄食试验法以0.005%杀鼠灵毒饵饲毒(LFP法),观察并分析试鼠的死亡率与食毒量的关系。结果本次褐家鼠抗性检测合格试鼠计37只,检测结束后试鼠因药物死亡29只,试鼠对杀鼠灵的抗性发生率为21.62%,已经形成抗性种群;死亡试鼠性别间在致死剂量和死亡时间上差异均无统计学意义(P>0.05);全部死亡试鼠平均食毒剂量为(19.14±5.44)mg/kg,平均死亡时间(7.34±3.51)d。结论湛江市区的褐家鼠防治应选用第一代抗凝血灭鼠剂以外的药物,同时注意监测害鼠对药物的敏感度变化,以节省有限的药物资源。
Objective To detect the level of resistance of first generation anticoagulant rodenticides collected from Rattus norvegicus collected from Zhanjiang City, Guangdong Province. Methods After the Rattus norvegicus caught in Zhanjiang City was pre-tested for a period of time indoors, the non-selective feeding test was used to test the toxicity of the rat poisoned with 0.005% warfarin (LFP method) The relationship between the rate and the amount of food poisoning. Results The resistance of Rattus norvegicus was tested in 37 rats. After the test, 29 rats died of the drug, 21.62% of the test rats showed resistance to warfarin, and the resistant population was formed. There was no significant difference in the lethal dose and the time of death among the sexes (P> 0.05). The average dose of the poisoning dose of all the dead mice was (19.14 ± 5.44) mg / kg and the average death time was (7.34 ± 3.51) days. Conclusion Rattus norvegicus prevention and treatment in Zhanjiang should use drugs other than the first-generation anticoagulant rodenticides. At the same time, attention should be paid to monitoring the sensitivity of the rats to the change of drugs, so as to save limited drug resources.